What question did this study set out to answer?

This research aims to investigate cellular and microenvironmental differences in sarcomatoid renal cell carcinoma compared to clear cell variants.

March 15, 2026

Abstract B035: Spatial multi-omic profiling of sarcomatoid and rhabdoid renal cell carcinoma reveals spatially distinct immune and tumor cell populations

Puntos clave

This research aims to investigate cellular and microenvironmental differences in sarcomatoid renal cell carcinoma compared to clear cell variants.
Conducted spatial multi-omic characterization of tumor regions in seven clear cell renal cell carcinoma patients with sarcomatoid features.
Utilized the G4X spatial multi-omic platform for quantifying RNA transcripts and protein targets.
Analyzed T-cell infiltration and tumor cell gene expression across different carcinoma types.
Sarcomatoid regions showed increased T-cell infiltration and higher B cell/plasma cell abundance than clear cell regions.
Differential gene expression analysis revealed activation markers in sarcomatoid T cells.
Tumor cells from sarcomatoid regions exhibited upregulation of antigen-presentation genes and epithelial–mesenchymal transition-related genes.

Resumen

Abstract Background: Rhabdoid and sarcomatoid (S/R) renal cell carcinoma (RCC) is a form of dedifferentiated RCC that can arise in the background of any RCC subtype. S/R features are associated with a more aggressive tumor phenotype and worse patient prognosis. Paradoxically, tumors with S/R differentiation demonstrate heightened sensitivity to immune checkpoint inhibitors (ICI) compared with their non-S/R counterparts. The mechanisms that drive this aggressive tumor phenotype and paradoxical ICIs sensitivity remain unclear. Prior studies have shown minimal genetic differences between S/R and non-S/R RCC, suggesting that non-genetic mechanisms drive this phenotype. Spatial multi-omic approaches are uniquely positioned to dissect the cellular and microenvironmental programs underlying S/R biology. Using a cohort of seven treatment-naïve patients with clear cell RCC (ccRCC) with S/R features, we performed spatial multi-omic characterization of tumor regions with sarcomatoid, rhabdoid, and/or ccRCC histology captured on the same tissue sections. Methods: Hematoxylin and eosin (H 2026 Mar 13-16; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2026;86 (5Suppl₂): Abstract nr B035.

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