The lowest quartile of myocardial contraction fraction was associated with increased risk of sudden cardiac death compared to higher quartiles (p=0.0244).
Does myocardial contraction fraction (MCF) measured by cardiac MRI predict sudden cardiac death and correlate with functional capacity in patients with hypertrophic cardiomyopathy?
Myocardial contraction fraction (MCF) derived from cardiac MRI is a superior marker compared to LVEF for correlating with functional status and predicting sudden cardiac death in patients with hypertrophic cardiomyopathy.
Tasa de eventos absoluta: 0% vs 0%
Background: The myocardial contraction fraction (MCF) is a volumetric index of myocardial shortening, defined as the ratio of LV stroke volume to myocardial volume. We hypothesize that MCF: may be associated with delayed enhancement, is correlated with functional capacity and is associated with SCD in HCM.Methods: As part of a multicenter study in which CMR was performed in 1293 consecutive HCM subjects (age 46±17 years, 63% males), we calculated the MCF as MCF=SV/MV. We explored associations between quartiles of MCF with demographic and clinical characteristics as well as outcomes.Results: The MCF was 65±20 (IQR 51-79) while EF was 67±9% in this cohort with HCM and average NYHA class of 1.6±0.7. MCF was strongly associated with NYHA class (p<0.001) while LVEF did not appear to have any relation (p=0.71). Lower MCF was the result of both a lower SV and higher myocardial volume. MCF was also associated with male gender, LVOT gradient, number of risk factors for sudden death and delayed enhancement (p<0.05). The lowest quartile of MCF was also associated with a greater risk of SCD than higher quartiles (p=0.0244 by log-rank).
Maurer et al. (Tue,) reported a other. The lowest quartile of myocardial contraction fraction was associated with increased risk of sudden cardiac death compared to higher quartiles (p=0.0244).