Our findings reveal that the enhanced resistance is primarily due to a functional specialization of the P1 efflux channel in RE-CmeB. This elucidation, strongly supported by the concordance between computational predictions and experimental data, provides a mechanistic basis and high-value targets (Q87/K89) for the development of efflux pump inhibitors against multidrug-resistant Campylobacter.
Yao et al. (Wed,) studied this question.