Vessel tome regulating function of endothelium in patients with bronchial asthma

Objective: to study the vessel tone regulating function of endothelium in patients with bronchial asthma(BA). Vasomotor function of endothelium has been investigated with the ultrasonic device VividTM-S6. We studied 126 patients with BA with out of a disease exacerbation. The 1st group included 29 patients with mild BA, the 2nd group-32 persons with middle BA, the 3rd group-40 people with severe non-steroid BA, the 4th group-25 patients with steroid BA. The group of control included 27 healthy volunteers. We found that at the peak the changes in final and initial diameters of humeral artery in group with severe BA were lower than in the control group(p<0.05). Besides, in this group depression of endothelium-dependent vasodilatation(EDV) was lower by 10%. In the 2nd group the tendency to depression of EDV(p=0.091) was found. In the 1st group EDV didn't differ from the control values, however in the individual analysis EDV depression was lower by 10% in 48.3% of the cases. We found that the initial diameter of humeral artery was higher in group of patients with BA and arterial hypertension(AG). The sensitivity coefficient to a shift strain as the marker of disturbance of an EDV was lower in patients with BA with AG in comparison with patients without AG(p=0.029). Insufficient reaction in reply to a reactive hyperemia(EDV<10%) was observed more often in patients with BA with AG in comparison with patients without AG(79.2% and 49.3%, x 2 =10.4) and group of control(38%). Our finding suggest that alterations in vessel tome regulating function of endothelium become to be more prominent along with BA progression, and have maximal expression in patients with BA and AG.