Copper‐mediated carbon–carbon bond formation reactions are significant transformations in organic synthesis. In this context, Cadiot–Chodkiewicz cross‐coupling reaction has played a pivotal role in the designing of natural products, offering an efficient and powerful way to build intricate polyacetylenes. This account provides recent applications of Cadiot–Chodkiewicz coupling reaction toward the total synthesis of polyacetylene‐based natural products.
Sohail et al. (Mon,) studied this question.