Subcellular marker staining is very important in clinical diagnosis and biological research. In this study, a peptide-protected platinum cluster probe with functional nuclear targeting was developed. The intrinsic fluorescence and catalytic properties of the prepared TAT-Pt cluster probe were characterized by tube experiments, and the dual-mode labeling imaging of nuclei was realized using the excellent fluorescence and catalytic activities of the prepared TAT-Pt cluster probe. The results suggest that the TAT peptide-protected platinum clusters are promising candidates for specific cell nuclei staining. These cluster probes provide an alternative choice for the labeling and analysis of single cell.
Yin et al. (Sun,) studied this question.