Warfarin provided more stable anticoagulation than acenocoumarol in patients with mechanical heart valves and atrial fibrillation, achieving a higher mean time in therapeutic range (76.1% vs 69.1%).
Cohort (n=73)
No
Does warfarin improve anticoagulation control stability compared to acenocoumarol in patients with mechanical heart valves and atrial fibrillation?
Warfarin may provide more stable anticoagulation control than acenocoumarol in patients with mechanical heart valves and atrial fibrillation, though larger prospective studies are needed to confirm.
Tasa de eventos absoluta: 76.1% vs 69.1%
Our unadjusted descriptive results suggested that warfarin, compared to acenocoumarol, may provide more stable and therefore safer anticoagulation control in patients with mechanical heart valves and atrial fibrillation. To confirm this, larger prospective clinical studies are needed in patients with mechanical heart valves with or without atrial fibrillation.
Toskić et al. (2026) conducted a cohort in Mechanical heart valves and atrial fibrillation (n=73). Warfarin vs. Acenocoumarol was evaluated on Time in therapeutic range (TTR). Warfarin provided more stable anticoagulation than acenocoumarol in patients with mechanical heart valves and atrial fibrillation, achieving a higher mean time in therapeutic range (76.1% vs 69.1%).
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