Abstract:: Ischemic stroke constitutes a significant contributor to mortality and long-term impairment worldwide. Over the past few decades, anti-ischemic medicines have made substantial progress. However, ischemic stroke remains an extremely challenging condition. Pomegranate (Punica granatum L.) fruits have been widely used in the treatment of various diseases since ancient times. Pomegranate is a nutrient-dense fruit that has a variety of phytochemicals, which are responsible for its antioxidative, antiapoptosis, and anti-inflammatory potential. This review presents evidence from experimental and clinical studies on the efficacy of pomegranate and its bioactive compounds, such as ellagic acid and gallic acid, in enhancing neurological and memory performance, reducing brain injury, preserving brain DNA integrity, and exhibiting antioxidant and antiinflammatory properties in ischemic stroke. These findings now indicate the therapeutic potential of pomegranate and its derivatives in stroke treatment and also hint at the direction further studies on their clinical applications and mechanisms of action should take.
Azami et al. (Thu,) studied this question.