The GG genotype of GLCCI1 rs37973 was independently associated with an annual FEV1 decline of ≥30 mL in Japanese asthma patients receiving long-term inhaled corticosteroids.
Cohort (n=224)
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Does the GLCCI1 variant accelerate pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment?
The GLCCI1 rs37973 GG genotype is an independent risk factor for accelerated pulmonary function decline in Japanese asthma patients on long-term inhaled corticosteroids.
Background: Several gene variants are associated with inhaled corticosteroid (ICS) treatment with a short-term response in steroid-naive patients with asthma, which are mostly observed in Caucasians; their presence needs confirmation across the ethnicities. In this study, we aimed to determine the relationship between the annual decline in forced expiratory flow volume in one second (FEV 1 ) and the variant of the glucocorticoid-induced transcript 1 gene ( GLCCI1 ) in Japanese patients with asthma receiving long-term ICS treatment, taking into account the effect of high serum periostin levels, a known association factor of pulmonary function decline and a marker of refractory eosinophilic/Th2 inflammation. Methods: In this study, 224 patients with asthma receiving ICS treatment for at least 4 years were enrolled from a cohort study of the Kinki-Hokuriku Airway disease Conference. The effects of a single nucleotide polymorphism in GLCCI1 on the decline in FEV 1 of 30 mL·yr -1 or greater were determined. Results: In addition to the known contributing factors, i.e., the most intensive treatment step, ex-smoking, and high serum periostin levels (≥95ng/mL), the GG genotype of GLCCI1 rs37973 was independently associated with a decline in FEV 1 of 30 mL·yr -1 or greater. When patients were stratified according to their serum periostin levels, the GG genotype of rs37973 was significantly associated with blood eosinophilia (≥250/μL) in the high serum periostin group. Conclusions: A GLCCI1 variant is a risk factor of pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment. Thus, GLCCI1 may be associated with response to ICS across ethnicities.
Izuhara et al. (Mon,) conducted a cohort in Asthma (n=224). GLCCI1 rs37973 GG genotype was evaluated on Decline in FEV1 of ≥30 mL/year. The GG genotype of GLCCI1 rs37973 was independently associated with an annual FEV1 decline of ≥30 mL in Japanese asthma patients receiving long-term inhaled corticosteroids.