Interferon Regulatory Factor 3 as a Mediator and Therapeutic Target in Innate Immune-Driven Corneal Stromal Inflammation and Opacity

Puntos clave

• The research aims to explore IRF3's role in innate immune-driven corneal inflammation and its potential as a therapeutic target.
• Utilized genetic and pharmacologic approaches to inhibit IRF3
• Measured cytokine and myeloid responses following IRF3 inhibition
• Evaluated the effects of piceatannol as a potential therapy
• Inhibition of IRF3 reduced cytokine production
• Decreased myeloid immune responses were observed
• Piceatannol offered a therapeutic avenue for maintaining corneal clarity