On the Origin of the Brain Semi‐Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale

Puntos clave

• The study aims to clarify the sources of HOD in the brain following deuterated substrate administration.
• Administered [6,6-2H2]fructose and [6,6-2H2]glucose as metabolic substrates.
• Measured HOD concentrations in the brain post-administration.
• Conducted control experiments to assess body-related HOD contributions.
• Initial HOD increase in the brain primarily due to body production of HOD.
• Deuterated substrates significantly raise HOD in the brain.
• Caution needed in interpreting HOD concentrations for organ-specific metabolism.