Higher dietary iron intake was associated with reduced odds of chronic daily headache in FTO A allele carriers (P=0.042), with no significant association observed in TT genotype carriers.
Case-Control (n=300)
Does dietary iron intake interact with FTO genotype to affect the odds of chronic daily headache in adults aged 40 to 80 years?
Higher dietary iron intake is associated with reduced odds of chronic daily headache specifically in carriers of the FTO A allele, suggesting a gene-nutrient interaction.
Tasa de eventos absoluta: 17.1% vs 18.63%
valor p: p=0.023
Background: Chronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype. Methods: This case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40 to 80 years. Participants were assessed for anthropometric assessments, assessment of food intake using a validated food frequency questionnaire, and FTO genotype. The association between dietary iron intake and CDH stratified by FTO genotype was assessed using logistic regression analysis after adjusting for age, gender, body mass index (BMI), physical activity, energy intake, and hypertension. Results: Among individuals with AT/AA genotypes, those with CDH had lower dietary iron intake than controls (17.10 ± 4.02 vs. 18.63 ± 4.62 mg/day, p = 0.023). Logistic regression after full adjustment found an inverse association between dietary iron and CDH in AT/AA genotype carriers (P = 0.042). No significant association was observed in TT genotype carriers. Conclusion: Dietary iron intake may be associated with a reduced odds of CDH in FTO A allele carriers, but no association was observed in TT genotype carriers, suggesting a gene-nutrient interaction in the prevention and management of CDH. Further studies are necessary to substantiate these findings.
Shekari et al. (Tue,) conducted a case-control in Chronic daily headache (n=300). Dietary iron intake vs. Healthy controls was evaluated on Odds of chronic daily headache stratified by FTO genotype (p=0.023). Higher dietary iron intake was associated with reduced odds of chronic daily headache in FTO A allele carriers (P=0.042), with no significant association observed in TT genotype carriers.