METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs

Resultado clave

METTL14 promotes lipid metabolism and inhibits atherogenesis by activating PPAR-α/γ expression and fatty acid oxidation in vascular smooth muscle cells.

Puntos clave

• The research aims to explore how METTL14 influences lipid metabolism and atherogenesis through PPAR-α/γ expression.
• Experimental models were used to assess the effects of METTL14 on PPAR-α/γ expression.
• Lipid metabolism was evaluated in vascular smooth muscle cells (VSMCs).
• Atherogenesis was analyzed through physiological assessments of arterial health.
• METTL14 significantly enhances the expression of PPAR-α/γ.
• Increased PPAR-α/γ leads to improved fatty acid oxidation.
• Inhibition of atherogenesis was observed in models with active METTL14.