Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous multi-organ manifestations and poorly understood pathogenesis.The variable therapeutic outcomes and potential for cross-indication treatments underscore the need to identify pivotal disease-driving signaling pathways for developing innovative and safer regimens.By categorizing the pathogenesis of SLE into three interconnected stages involving over-activated immune response, skewed cytokine homeostasis, and impaired debris clearance, and analyzing public clinical data, this review posits that the Janus kinase-signal transducer and activator of transcription (JAK/STAT) axis is a central driver of SLE pathogenesis.Accordingly, it explores the potential of cold atmospheric plasma (CAP) to modulate this pathway for therapeutic benefit that require further experimental and clinical validations.
Dai et al. (Tue,) studied this question.