SGLT2 inhibition reverses abnormal renal oxygenation in obesity and type 2 diabetes, supporting multiparametric kidney MRI as a non-invasive tool to track therapeutic response.
Low serum albumin, hyponatremia, and elevated systolic blood pressure are strong, modifiable predictors of rapid kidney function decline in adults with CKD in Northern Tanzania.
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Conclusion: Multiparametric kidney MRI sensitively captures stagedependent hemodynamics, structural change, and oxygenation in obesity and T2D.SGLT2 inhibition demonstrates reversal of abnormal renal oxygenation, evidenced by favorable changes in medullary FSOC.These findings support multiparametric MRI as a non-invasive biomarker suite to track progression and therapeutic response in early diabetic kidney disease.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Akrabi et al. (Wed,) reported a other. SGLT2 inhibition reverses abnormal renal oxygenation in obesity and type 2 diabetes, supporting multiparametric kidney MRI as a non-invasive tool to track therapeutic response.