UFC remained an independent predictor of the primary combined outcome (adjusted HR 2.05, p=0.011) and all-cause mortality (adjusted HR 4.08, 95% CI 1.07-15.55,p=0.039), while the secondary renal composite showed a similar but non-significant trend (HR 1.83, p=0.115).Baseline eGFR was a consistent protective factor (p<0.01). Conclusion:Higher urinary uPTM-FetA/creatinine ratio (UFC) was independently associated with increased risks of the combined renal and mortality outcome and all-cause mortality in CKD stages 2-4.Reflecting tubular hypoxia and fibrosis, UFC may serve as a sensitive, non-invasive biomarker for early risk stratification and prognosis in CKD.I have potential conflict of interest to disclose.
Tatsumi et al. (Wed,) studied this question.