WCN26-6223 Differences in renal pathological features between IgA nephropathy and IgA vasculitis: Investigation on the basis of M2 macrophage infiltration

Results: Complete clinical remission, defined as resolution of edema and normalization of urinary protein excretion, was achieved within two months without reported adverse events.Conclusion: This first reported case demonstrates the feasibility of immunosuppressant-free induction therapy with telitacicept in PLN.The rapid reduction in proteinuria and absence of infections and reproductive toxicity challenge the necessity of traditional immunosuppressants, suggesting a paradigm shift toward targeted biologic therapies.Further studies are warranted to validate this approach.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.