What question did this study set out to answer?

The study aims to investigate the familial aggregation patterns of Darwin’s tubercle and their sex-bias in a specific tribal population.

March 28, 2026Open Access

Sex-Biased Familial Aggregation of Darwin’s Tubercle in an Eastern Indian Tribal Population

Puntos clave

The study aims to investigate the familial aggregation patterns of Darwin’s tubercle and their sex-bias in a specific tribal population.
Examined 416 parent-offspring pairs from the Lodha PVTG
Used statistical analysis to assess familial aggregation patterns
Analyzed sex-specific associations in various parental pathways
Significant associations found across all parental pathways
Strongest aggregation observed in father-son pairs
Findings support non-Mendelian inheritance with potential sex-based influences

Resumen

Darwin’s tubercle (DT) is a minor auricular trait showing wide inter-population variation and non-Mendelian patterns of familial aggregation. This study examines sex-biased parent–offspring aggregation of DT in an Eastern Indian tribal population (Lodha PVTG), using 416 parent–offspring pairs. Significant associations were observed across all parental pathways (Chi² = 28.45–86.49; p < 0.001), with strongest aggregation in father–son pairs. The findings support autosomal expression with sex-specific penetrance and developmental modulation.

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