What question did this study set out to answer?

This research aims to evaluate how well the PANOMEN-3 classification predicts adrenal and thyroid dysfunction in patients with pituitary adenomas.

March 28, 2026Open Access

Prognostic value of PANOMEN-3 classification for hypopituitarism in surgically and nonoperatively managed pituitary adenomas

This research aims to evaluate how well the PANOMEN-3 classification predicts adrenal and thyroid dysfunction in patients with pituitary adenomas.
Analyzed the PANOMEN-3 grading system.
Included surgically and nonoperatively managed pituitary adenoma cases.
Assessed risk stratification for secondary adrenal and thyroid dysfunction.
PANOMEN-3 grading effectively identifies patients at increased risk for adrenal dysfunction.
The classification successfully predicts thyroid dysfunction in both treatment cohorts.
Overall, it enhances clinical decision-making regarding patient management.

PANOMEN-3 grading effectively stratifies the risk of secondary adrenal and thyroid dysfunction in both surgical and nonoperative settings.

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Afif Nakhleh

Bar-Ilan University

Gida Ayada

Rabin Medical Center

Mai Assalia Naffa

Rambam Health Care Campus

Endocrine Connections

Technion – Israel Institute of Technology

Bar-Ilan University

Rambam Health Care Campus

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