Macrophage β-catenin-Ihh axis induces hepatic stellate cell activation and fibrosis in metabolic dysfunction-associated steatohepatitis | Synapse
March 30, 2026Open Access
Macrophage β-catenin-Ihh axis induces hepatic stellate cell activation and fibrosis in metabolic dysfunction-associated steatohepatitis
Puntos clave
To determine the role of the macrophage β-catenin-Ihh axis in hepatic steatosis and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).
Investigated the macrophage β-catenin-Ihh signaling pathway
Examined its effects on hepatic stellate cells
Analyzed conditions of metabolic dysfunction-associated steatohepatitis
Identified macrophage β-catenin-Ihh axis as a key regulator
Showed activation of hepatic stellate cells due to this axis
Demonstrated a significant correlation with increased fibrosis in liver tissues
Resumen
Our findings identify the macrophage β-catenin-Ihh axis as a key regulator for controlling hepatic steatosis and fibrosis during MASH.