Proliferation-dependent adipogenic differentiation of progenitor cells in rat coronary artery explants

Puntos clave

• This research investigates how proliferation affects the differentiation of progenitor cells into adipocytes in coronary artery explants.
• Used rat coronary artery explants to study progenitor cell behavior.
• Focused on Gli1+ progenitors and their role in adipogenesis.
• Analysed the relationship between cell proliferation and adipogenic differentiation.
• Demonstrated that early proliferation is necessary for the initiation of adipogenic differentiation.
• Identified mechanisms that may contribute to coronary vascular remodelling associated with disease.