Introduction: Fenugreek is an herb from the Fabaceae family, rich in phytochemicals like diosgenin and trigonelline, whose antioxidant and anti-inflammatory properties make it a candidate for managing cancer and aging. Methods Relevant studies were obtained from PubMed, Web of Science, Scopus, and Embase databases from January 2000 until April 2024. Following, two independent reviewers assessed the retrieved articles for inclusion and exclusion criteria based on their titles, abstracts, and full texts. Results Of the 1280 studies, 231 were included in the current study. The mechanisms by which Fenugreek, diosgenin, and trigonelline manage aging and cancer were reviewed. Radical scavenging, inflammatory, and tumorigenesis pathways suppressions, including NF/κB and Wnt-β-catenin, were the main modes of action. G0/G1 and G2/M cell cycle phase arrest were another crucial mechanism for stopping cancerous cells’ proliferation. Discussion/Conclusions: This study offers valuable insights into the potential application of fenugreek, diosgenin, and trigonelline as complementary therapies for managing cancer and aging.
Shahrahmani et al. (Wed,) studied this question.