Phytochemical profiling of Euphorbia tirucalli Linn. latex and evaluation of its in vitro antibacterial activity against resistant Klebsiella pneumoniae : an integrative network pharmacology and molecular dynamics simulation study | Synapse
April 1, 2026Open Access
Phytochemical profiling of Euphorbia tirucalli Linn. latex and evaluation of its in vitro antibacterial activity against resistant Klebsiella pneumoniae : an integrative network pharmacology and molecular dynamics simulation study
Puntos clave
The main aim is to evaluate the antibacterial properties of Euphorbia tirucalli latex against resistant Klebsiella pneumoniae and identify potential target interactions.
Conducted phytochemical profiling of Euphorbia tirucalli latex metabolites.
Assessed antibacterial activity through in vitro experiments against Klebsiella pneumoniae.
Utilized network pharmacology and molecular dynamics simulations to support target interaction findings.
Euphorbia tirucalli latex metabolites demonstrated modest antibacterial activity against the resistant strain of Klebsiella pneumoniae.
Network pharmacology suggests potential therapeutic targets related to lactate metabolism and membrane integrity.
Resumen
Euphorbia tirucalli latex metabolites showed modest antibacterial activity against resistant Klebsiella pneumoniae ; network pharmacology and molecular modeling supported putative target interactions.