August 2, 2023Open Access
Ver artículo completoHypertriglyceridemia-Associated Pancreatitis: New Concepts and Potential Mechanisms
PICO estructurado
Does plasma triglyceride-lowering therapy prevent acute pancreatitis in individuals with mild to moderate hypertriglyceridemia?
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Población
Individuals with mild to moderate hypertriglyceridemia
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Intervención
Plasma triglyceride-lowering therapy targeting the pathway for lipoprotein lipase (blocking Angiopoietin-like 3 and apolipoproteinC-III)
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Resultado
Acute pancreatitis
Mild to moderate hypertriglyceridemia is causally linked to acute pancreatitis, suggesting an unmet need that could potentially be addressed by novel triglyceride-lowering therapies.
Resumen
Recent observational and genetic studies indicate that mild to moderate hypertriglyceridemia is causally related to increased risk of acute pancreatitis, most likely as a marker of future severe hypertriglyceridemia. Current guidelines do not mention individuals with mild to moderate hypertriglyceridemia, even though newer evidence suggests an unmet medical need. Treatment could include plasma triglyceride-lowering therapy targeting the pathway for lipoprotein lipase as the main triglyceride degrading enzyme in plasma. Angiopoietin-like 3 and apolipoproteinC-III are inhibitors of lipoprotein lipase, and blocking of these 2 inhibitors is showing promising results in relation to marked triglyceride-lowering and could perhaps be used to prevent acute pancreatitis in the future.