Development and validation of the modified-comprehensive Kumamoto Score: a multi-organ assessment tool for hereditary transthyretin amyloidosis

Puntos clave

• To develop and validate a comprehensive assessment tool for hereditary transthyretin amyloidosis (ATTRv).
• Created the modified-Kumamoto Score (mKS) for multi-organ assessment.
• Validated sensitivity and specificity of the mKS in early-stage disease.
• Included organ-specific subscales for detailed evaluation.
• The mKS showed enhanced sensitivity compared to previous tools.
• Validated for assessing multiple organs affected by ATTRv.
• Addresses critical needs for monitoring in light of disease-modifying therapies.