What question did this study set out to answer?

The aim is to identify effective approaches for treating persistent atrial fibrillation, focusing on left atrial structures.

April 4, 2026Open Access

Rotor-Guided Tailor-Made Pulmonary Vein Isolation for Persistent Atrial Fibrillation: Identification of the Left Atrial Septum as a Common Arrhythmogenic Substrate

Resultado clave

Rotor-guided extended pulmonary vein isolation significantly improved 12-month freedom from atrial fibrillation recurrence compared to PVI alone or PVI plus PWI (p=0.004).

Puntos clave

The aim is to identify effective approaches for treating persistent atrial fibrillation, focusing on left atrial structures.
Utilized rotor-guided techniques for pulmonary vein isolation (PVI)
Compared outcomes between rotor-guided extended PVI and traditional PVI methods
Employed log rank test for statistical analysis of arrhythmia recurrence
Freedom from atrial fibrillation or atrial tachycardia improved in rotor-guided extended PVI group
Significant p-value of 0.004 indicating strong evidence against no difference between groups

PICO estructurado

Does rotor-guided extended PVI reduce AF/AT recurrence in patients with persistent atrial fibrillation?

Población

Patients with persistent atrial fibrillation (PerAF) undergoing initial catheter ablation

Intervención

Rotor-guided extended PVI (cryoballoon PVI followed by radiofrequency line extension to encompass adjacent AF rotors identified by ExTRa Mapping)

Comparador

Cryoballoon PVI alone or radiofrequency-based PVI plus posterior wall isolation (PWI)

Resultado

Freedom from AF/AT recurrence without antiarrhythmic drugs at 12 months

A tailored ablation strategy combining cryoballoon PVI with ExTRa Mapping-guided radiofrequency ablation of adjacent rotors significantly reduces AF/AT recurrence in patients with persistent atrial fibrillation without increasing iatrogenic atrial tachycardia.

Resultado numérico

Tasa de eventos absoluta: 0% vs 0%

Resumen

Log rank test, p = 0.004 Follow-up (months) Freedom from AF/AT recurrence 0 2 4 6 8 10 12 1.0 0.8 0.6 0.4 0.2 0 Number at risk Rotor-guided extended PVI group PVI-alone group PVI plus PWI group Rotor-guided extended PVI group PVI-alone group PVI plus PWI group

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Cite This Study

Suzuki et al. (Wed,) reported a other. Rotor-guided extended pulmonary vein isolation significantly improved 12-month freedom from atrial fibrillation recurrence compared to PVI alone or PVI plus PWI (p=0.004).

synapsesocial.com/papers/69d0adc2659487ece0fa4534 https://doi.org/https://doi.org/10.1016/j.hroo.2026.03.029

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