Abstract Pediatric-type follicular lymphoma (PTFL) is a rare, indolent B-cell neoplasm accounting for BCL2 rearrangements and shows recurrent mutations of MAP2K1 and TNFRSF14 genes. The disease has an excellent prognosis, with 5-year overall survival over 95% and extremely low progression rates. The management is usually conservative after complete surgical excision. In this review, we highlight the unique clinical-pathological and biological features of PTFL, with a focus on its differential diagnosis and on potential therapeutic approaches.
Dellea et al. (Wed,) studied this question.