Integration of Sonosensitive Nanomicelles and Ultrasound for Enhanced BBB Penetration and Targeted Therapy against Glioblastoma: Intravenous Injection vs. Intranasal Dripping | Synapse
April 4, 2026Materials Chemistry Frontiers0 citations
Integration of Sonosensitive Nanomicelles and Ultrasound for Enhanced BBB Penetration and Targeted Therapy against Glioblastoma: Intravenous Injection vs. Intranasal Dripping
To investigate how ultrasound combined with sonosensitive nanomicelles improves drug delivery across the blood brain barrier in treating glioblastoma.
Utilized sonosensitive nanomicelles to enhance drug penetration through the blood brain barrier.
Compared intravenous injection and intranasal dripping for delivering the nanomicelles.
Applied ultrasound to facilitate drug release and distribution in brain tissues.
Ultrasound significantly improved the penetration of nanomicelles across the blood brain barrier.
Intranasal delivery showed comparable or improved effectiveness compared to intravenous injection.
Enhanced drug delivery resulted in reduced tumor growth in models of glioblastoma.
Resumen
The blood brain barrier (BBB) is pivotal to protect brain from external interferences and to maintain homeostasis for normal physiological processes. However, it also becomes a vital obstacle for drug...