November 30, 2006Open Access

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

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Resumen

Genetic deletion of Ccr5 but not Ccr1 in ApoE-/- mice protects from diet-induced atherosclerosis, associated with a more stable plaque phenotype, reduced mononuclear cell infiltration, Th1-type immune responses, and increased interleukin-10 expression. This corroborates CCR5 as a promising therapeutic target.

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Cite This Study

Braunersreuther et al. (Thu,) studied this question.

synapsesocial.com/papers/69d11275dc4fa05cbc79a4ea https://doi.org/https://doi.org/10.1161/01.atv.0000253886.44609.ae

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