How do left atrial remodeling and function differ between advanced HFrEF and HFpEF, and how do they impact clinical outcomes?
Left atrial function is more closely associated with clinical outcomes in HFpEF compared to HFrEF, highlighting it as a potential therapeutic target in HFpEF.
HFrEF is characterized by greater eccentric LA remodeling, whereas HFpEF by increased LA stiffness, which might contribute to greater atrial fibrillation burden. LA function is associated with pulmonary vascular disease and right HF in both HF phenotypes, but is associated with outcome more closely in HFpEF, supporting efforts to improve LA function in this cohort.
Melenovský et al. (2015) studied this question.