Is left anterior descending coronary artery radiation dose associated with major adverse cardiac events and mortality in patients with non-small cell lung cancer?
Optimal cardiac radiation dose constraints in patients with non-small cell lung cancer may need to be tailored based on the presence of preexisting coronary heart disease to mitigate the risk of MACE and mortality.
The findings of this cohort study suggest that optimal cardiac dose constraints may differ based on preexisting CHD. Although the LAD coronary artery V15 Gy greater than or equal to 10% appeared to be an independent estimator of the probability of MACE and all-cause mortality, particularly in patients without CHD, left ventricle V15 Gy greater than or equal to 1% appeared to confer an increased risk of MACE among patients with CHD. These constraints are worthy of further study because there is a need for improved cardiac risk stratification and aggressive risk mitigation strategies.
Atkins et al. (Fri,) studied this question.