January 1, 2016Open Access

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Associated With Ryanodine Receptor (RyR2) Gene Mutations　– Long-Term Prognosis After Initiation of Medical Treatment –

PICO estructurado

Does compliance with medical treatment and strict exercise restriction prevent recurrent cardiac events in RyR2-positive CPVT patients?

Población

RyR2-positive Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) patients

Intervención

Medical treatment and strict exercise restriction

Resultado

Recurrent cardiac events and high-risk ventricular arrhythmias (VAs) during exercise stress test (EST)hard clinical

Strict compliance with medical therapy and exercise restriction is essential to prevent fatal recurrent cardiac events in patients with RyR2-positive CPVT.

Resumen

Even after initiation of medical treatment, high-risk VAs were induced during EST in mostRyR2-positive CPVT patients. Most fatal recurrent cardiac events occurred in patients who were noncompliant with exercise restriction and/or medical therapy. Medical management including strict exercise restriction should be emphasized to prevent recurrent cardiac event in mostRyR2-positive CPVT patients. (Circ J 2016; 80: 1907-1915).

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