Intracranial Aneurysms and Sickle Cell Anemia: Multiplicity and Propensity for the Vertebrobasilar Territory

There are strong statistical associations for aneurysm multiplicity and sites of aneurysm occurrence among reported patients with sickle cell disease. Patients with sickle cell anemia and neurological symptoms should undergo magnetic resonance angiography or four-vessel angiography to detect potentially harmful, but neurosurgically treatable, pathological conditions.