March 16, 2017Open Access

Angiogenic Mechanisms of Human CD34 + Stem Cell Exosomes in the Repair of Ischemic Hindlimb

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Resumen

Collectively, our results have demonstrated a novel mechanism by which cell-free CD34Exo mediates ischemic tissue repair via beneficial angiogenesis. Exosome-shuttled proangiogenic miRNAs may signify amplification of stem cell function and may explain the angiogenic and therapeutic benefits associated with CD34+ stem cell therapy.

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Mathiyalagan et al. (Thu,) studied this question.

synapsesocial.com/papers/69d707e9a0177bf533ed9935 https://doi.org/https://doi.org/10.1161/circresaha.116.310557

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1miR-126 Regulates Angiogenic Signaling and Vascular Integrity2008 · 1,701 citations
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3Transcoronary Concentration Gradients of Circulating MicroRNAs2011 · 269 citations
4Clinical Potential of Adult Vascular Progenitor Cells2010 · 101 citations
5Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids2006 · 5,765 citations

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