Does the measurement of LDL-C, lipoprotein(a), and HDL-C levels in children from FH families allow accurate diagnosis and identification of highest CVD risk kindreds?
Lipid profiling in children from FH families is crucial for early diagnosis and identifying kindreds at the highest cardiovascular risk.
In FH families, LDL-C levels allow accurate diagnosis of FH in childhood. Moreover, increased LDL-C and lipoprotein(a) and decreased HDL-C levels in children identify FH kindreds with the highest CVD risk.
Wiegman et al. (Mon,) studied this question.
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