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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway | Synapse

March 21, 2014Open Access

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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

CWChristina M. WarboysRoyal Veterinary College ALAmalia de LucaMarche Polytechnic University NANarges AminiKowsar Hospital

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Resumen

Disturbed flow promotes endothelial senescence via a p53-p21-dependent pathway which can be inhibited by activation of sirtuin 1. These observations support the principle that pharmacological activation of sirtuin 1 may promote cardiovascular health by suppressing EC senescence at atheroprone sites.

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Cite This Study

Warboys et al. (Fri,) studied this question.

synapsesocial.com/papers/69d77542db9d5e1bf4b8ab65 https://doi.org/https://doi.org/10.1161/atvbaha.114.303415