Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.

Summary and ConclusionsA reproducible generalized or focal arthritis, synovitis, periostitis and tendonitis has been induced in rats by intracutaneous injections of a Freund-type adjuvant which was most potent when macerated striated muscle tissue was added to the inoculum. The pathogenetic mechanisms underlying the production of these changes is at present unclear.