Visible-Light Mediated Oxidative C–H/N–H Cross-Coupling between Tetrahydrofuran and Azoles Using Air

Tetrahydrofuran is a privileged structural moiety in many important organic compounds. In this work, we have developed a simple and mild catalytic oxidative amination of tetrahydrofuran mediated by visible-light catalysis. The C(sp3)-H bond of tetrahydrofuran was activated using molecular oxygen as a benign oxidant. Besides, a variety of azoles could be tolerated, providing a green route for N-substituted azoles.