June 12, 2009Open Access

Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

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Resumen

Human sperm DNA fragmentation is associated with an increase in oxidative stress during cryopreservation, rather than the activation of caspases and apoptosis. The estrogenic compound genistein may be useful in reducing this effect but larger trials are needed to confirm this.

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Thomson et al. (Fri,) studied this question.

synapsesocial.com/papers/69d7bcb3e57cdc1cc9ae2a39 https://doi.org/https://doi.org/10.1093/humrep/dep214

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Genistein inhibits protein histidine kinase.1992 · 154 citations
2The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity1998 · 236 citations
3Efficacy of the anticaspase agent zVAD-fmk on post-thaw viability of canine spermatozoa2003 · 33 citations
4Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus2008 · 129 citations
5The DNA integrity of cryopreserved spermatozoa separated for use in assisted reproductive technology is unaffected by the type of cryoprotectant used but is related to the DNA integrity of the fresh separated preparation2008 · 31 citations

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