May 19, 2009Open Access

Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes

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Resumen

We report the novel observation that levels of ligands of TLR2 and TLR4 are significantly elevated in type 1 diabetes, and this, in concert with hyperglycaemia, accounts for the increase in TLR2 and TLR4 activity, underscoring the proinflammatory state of type 1 diabetes.

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Devaraj et al. (Tue,) studied this question.

synapsesocial.com/papers/69d7dd7205ee2ba81dbee650 https://doi.org/https://doi.org/10.1007/s00125-009-1394-8

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1Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus2005 · 267 citations
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4Toll-like Receptors and Atherosclerosis: Key Contributors in Disease and Health?2006 · 69 citations
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