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Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice | Synapse

July 23, 2010Open Access

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Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

RMRadhika MuzumdarChildren's Hospital of Pittsburgh DHDerek M. HuffmanAlbert Einstein College of Medicine JCJohn W. CalvertHeart Failure / Cardiomyopathy

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Resumen

These data show that HNG provides cardioprotection in a mouse model of myocardial ischemia and reperfusion potentially through activation of AMPK-endothelial nitric oxide synthase-mediated signaling and regulation of apoptotic factors. HNG may represent a novel agent for the treatment of acute myocardial infarction.

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Cite This Study

Muzumdar et al. (Fri,) studied this question.

synapsesocial.com/papers/69d80a4145af6083e6ae2ab6 https://doi.org/https://doi.org/10.1161/atvbaha.110.205997