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Safety of Recombinant Activated Factor VII in Randomized Clinical Trials | Synapse

November 3, 2010Open Access

Safety of Recombinant Activated Factor VII in Randomized Clinical Trials

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Resumen

In a large and comprehensive cohort of persons in placebo-controlled trials of rFVIIa, treatment with high doses of rFVIIa on an off-label basis significantly increased the risk of arterial but not venous thromboembolic events, especially among the elderly. (Funded by Novo Nordisk.).

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Cite This Study

Levi et al. (Wed,) studied this question.

synapsesocial.com/papers/69d80adb45af6083e6ae2ac2 https://doi.org/https://doi.org/10.1056/nejmoa1006221

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Elective administration in infants of low-dose recombinant activated factor VII (rFVIIa) in cardiopulmonary bypass surgery for congenital heart disease does not shorten time to chest closure or reduce blood loss and need for transfusions: a randomized, double-blind, parallel group, placebo-controlled study of rFVIIa and standard haemostatic replacement therapy versus standard haemostatic replacement therapy2006 · 109 citations
2Inhibitor Development in a Multitransfused Patient with Severe Haemophilia A1999 · 105 citations
3Factor VIIa and its potential therapeutic use in bleeding-associated pathologies2008 · 70 citations
4Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery2007 · 1,391 citations
5Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials2005 · 785 citations