August 21, 2013Open Access

Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: results of a randomized, vehicle-controlled trial

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Resumen

A single intradermal injection of allogeneic fibroblasts increases the initial rate of erosion healing in subjects with RDEB within the first 28 days but not thereafter. Further studies are needed to address the potential benefits of retreatment as well as optimal cell delivery.

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Cite This Study

Petrof et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8164db5518339b2ae2b73 https://doi.org/https://doi.org/10.1111/bjd.12599

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1HB-EGF Induces COL7A1 Expression in Keratinocytes and Fibroblasts: Possible Mechanism Underlying Allogeneic Fibroblast Therapy in Recessive Dystrophic Epidermolysis Bullosa2011 · 69 citations
2Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial2012 · 173 citations
3Tissue-Engineered Skin (Apligraf) in the Healing of Patients With Epidermolysis Bullosa Wounds2000 · 177 citations
4Epidermolysis Bullosa Acquisita Antigen Is Synthesized by Both Human Keratinocytes and Human Dermal Fibroblasts1985 · 100 citations
5A homozygous insertion–deletion in the type VII collagen gene (COL7A1) in Hallopeau–Siemens dystrophic epidermolysis bullosa1993 · 131 citations

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