Electron microscopical study of Coat's disease.

At the present time there is only one report in the literature on the ultrastructural changes to be found in Coats's disease and this is limited to a description of subretinal and intra- retinal "ghost cells" (Manschot and de Bruijn, I967). We have recently had an opportunity to carry out an electron microscopical examination of an early, typical case and, although our findings add little to existing knowledge of the aetiology of the condition, they are of value in interpreting the morbid histological appearances of conventional microscopy and in understanding its pathogenesis.