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Our data suggest that F-18-AV-1451 holds promise as a surrogate marker for the detection of brain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzheimer brains but also point to its relatively lower affinity for lesions primarily made of straight tau filaments in non-Alzheimer tauopathy cases and to the existence of some F-18-AV-1451 off-target binding. These findings provide important insights for interpreting in vivo patterns of F-18-AV-1451 retention.
Marquié et al. (Mon,) studied this question.