May 1, 2009Open Access

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor #

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Resumen

Our study suggests a new role for MDSCs in patients with HCC in disarming the innate immune system and further contributing to the immune suppressor network in these patients. These findings have important implications when designing immunotherapy protocols.

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Cite This Study

Hoechst et al. (Fri,) studied this question.

synapsesocial.com/papers/69d849c85c3030ff03d19af3 https://doi.org/https://doi.org/10.1002/hep.23054

Also Consider

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1Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor.1995 · 272 citations
2Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas2005 · 220 citations
3Human natural killer cells2008 · 1,893 citations
4Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma2004 · 137 citations
5Natural killer cell activity in patients with liver cirrhosis relative to severity of liver damage1991 · 27 citations

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