Low P27 Expression Predicts Poor Disease-Free Survival in Patients With Prostate Cancer

No AccessJournal of UrologyClinical Urology: Original Articles1 Mar 1998LOW P27 EXPRESSION PREDICTS POOR DISEASE-FREE SURVIVAL IN PATIENTS WITH PROSTATE CANCER RONALD M. YANG, JOHN NAITOH, MICHAEL MURPHY, HE-JING WANG, JULIA PHILLIPSON, JEAN B. DEKERNION, MASSIMO LODA, and ROBERT E. REITER RONALD M. YANGRONALD M. YANG More articles by this author , JOHN NAITOHJOHN NAITOH More articles by this author , MICHAEL MURPHYMICHAEL MURPHY More articles by this author , HE-JING WANGHE-JING WANG More articles by this author , JULIA PHILLIPSONJULIA PHILLIPSON More articles by this author , JEAN B. DEKERNIONJEAN B. DEKERNION More articles by this author , MASSIMO LODAMASSIMO LODA More articles by this author , and ROBERT E. REITERROBERT E. REITER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63776-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: p27 is an inhibitor of the cell cycle with potential tumor suppressor function. Decreased levels of p27 protein expression have been correlated with poor prognosis in patients with breast and colorectal carcinomas. Although as many as a third of patients with clinically localized prostate cancer will have relapse after radical prostatectomy, predicting who will have recurrence remains enigmatic. We examined the ability of p27 protein levels to predict outcome in patients with clinically localized disease who underwent radical prostatectomy. Materials and Methods: p27 protein expression was evaluated in 86 patients with clinical stage T1-2 prostate cancer who were treated with radical prostatectomy. Archived paraffin embedded specimens were sectioned and immunostained with p27 antibody, and scored by 2 independent observers in a blinded fashion. The absence or presence of p27 protein was then correlated with biochemical relapse in univariate and multivariate analyses. Results: In a multivariate analysis that included age, preoperative prostate specific antigen, Gleason score and pathological stage p27 was a strong independent predictor of disease-free survival (p = 0.0184, risk ratio 3.04), second only to pathological stage (p = 0.0001, risk ratio 6.73). Even more strikingly, multivariate analysis demonstrated that p27 was the strongest predictor of biochemical recurrence (p = 0.0081, risk ratio 4.99) among factors studied in patients with pathological T2a-T3b disease. Conclusions: Absent or low levels of p27 protein expression appear to be an adverse prognostic factor in patients with clinically organ confined disease treated by radical prostatectomy. 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Google Scholar From the Departments of Urology, Pathology and Biomathematics, UCLA School of Medicine, Los Angeles, California, and Department of Pathology, Beth Israel Deaconess Medical Center, West Campus, Harvard Medical School, Boston, Massachusetts.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFEBBO P and SELLERS W (2018) Use of Expression Analysis to Predict Outcome After Radical ProstatectomyJournal of Urology, VOL. 170, NO. 6S, (S11-S20), Online publication date: 1-Dec-2003.BEN-IZHAK O, LAHAV-BARATZ S, MERETYK S, BEN-ELIEZER S, SABO E, DIRNFELD M, COHEN S and CIECHANOVER A (2018) Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor p27Kip1 in Prostate CancerJournal of Urology, VOL. 170, NO. 1, (241-245), Online publication date: 1-Jul-2003.FREEDLAND S, deGREGORIO F, SACOOLIDGE J, ELSHIMALI Y, CSATHY G, DOREY F, REITER R and ARONSON W (2018) Preoperative p27 Status is an Independent Predictor of Prostate Specific Antigen Failure Following Radical ProstatectomyJournal of Urology, VOL. 169, NO. 4, (1325-1330), Online publication date: 1-Apr-2003.VIS A, NOORDZIJ M, FITOZ K, WILDHAGEN M, SCHRÖDER F and van der KWAST T (2018) PROGNOSTIC VALUE OF CELL CYCLE PROTEINS p27kip1 AND MIB-1, AND THE CELL ADHESION PROTEIN CD44s IN SURGICALLY TREATED PATIENTS WITH PROSTATE CANCERJournal of Urology, VOL. 164, NO. 6, (2156-2161), Online publication date: 1-Dec-2000.Taneja S (2018) EDITORIAL: MOLECULAR MARKERS OF CANCER PROGRESSION. 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Volume 159Issue 3March 1998Page: 941-945 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.Metrics Author Information RONALD M. YANG More articles by this author JOHN NAITOH More articles by this author MICHAEL MURPHY More articles by this author HE-JING WANG More articles by this author JULIA PHILLIPSON More articles by this author JEAN B. DEKERNION More articles by this author MASSIMO LODA More articles by this author ROBERT E. REITER More articles by this author Expand All Advertisement PDF downloadLoading ...