March 20, 2023

Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis

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Resumen

PD exacerbates atherosclerosis and impairs lipid metabolism in mice, which may be mediated by F. nucleatum-promoted glycolysis and lipogenesis through PI3K/Akt/mTOR signalling in hepatocytes. Treatment of PD and specific targeting of F. nucleatum are promising strategies to improve therapeutic effectiveness of hyperlipidaemia and atherosclerosis.

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Zhou et al. (Mon,) studied this question.

synapsesocial.com/papers/69d8924705ee2ba81dbefc6d https://doi.org/https://doi.org/10.1093/cvr/cvad045

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