Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke | Synapse
April 10, 2026Open Access
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke
Puntos clave
The research aims to investigate the role of the IRF7-CXCL10 axis in microglial programmed cell death (PCD) during ischemic stroke.
Conducted multi-omics analysis to examine the molecular pathways involved.
Performed experimental validation of the identified pathway in vitro and in vivo.
Utilized statistical methods to correlate findings with neuroinflammation levels.
Identified IRF7 as a critical regulator of CXCL10 expression.
Demonstrated that modulating the IRF7-CXCL10 axis impacts microglial PCD.
Established a link between neuroinflammation and ischemic stroke outcomes.
Resumen
Our findings uncover the IRF7-CXCL10 axis as a pivotal driver of detrimental neuroinflammation in ischemic stroke and establish IRF7 as a potent therapeutic target for neuroprotection.