What question did this study set out to answer?

The central aim is to examine the relationship between the TGF-β (+869 C/T) polymorphism and lung cancer risk, while evaluating quercetin as an inhibitor.

April 10, 2026Open Access

An Integrative Approach to Lung Cancer Therapy: Linking the TGF-β (+869 C/T) Polymorphism to a Structurally Validated Natural Inhibitor

Puntos clave

The central aim is to examine the relationship between the TGF-β (+869 C/T) polymorphism and lung cancer risk, while evaluating quercetin as an inhibitor.
Investigated the TGF-β pathway activity in relation to the polymorphism.
Analyzed the connection between the polymorphism and lung cancer susceptibility in the Iraqi population.
Provided structural validation of quercetin as an inhibitor of ALK5.
Identified a strong link between the TGF-β (+869 C/T) polymorphism and lung cancer susceptibility.
Confirmed quercetin as a promising natural inhibitor of the ALK5 pathway.

Resumen

This study established a strong connection between the activity of the TGF-β pathway, the +869C/T polymorphism, and lung cancer susceptibility in the Iraqi population. Additionally, it provided conclusive structural evidence supporting quercetin as a highly promising natural inhibitor of ALK5.

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Authors

Nawar Bahaa Abdulsahib

University of Technology - Iraq

Mohammed A. Hameed

Nahrain University

Ragheed Hussam Yousif

University of Technology - Iraq

Journals

Asian Pacific Journal of Cancer Prevention

Actions

Institutions

University of Technology - Iraq

Nahrain University

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An Integrative Approach to Lung Cancer Therapy: Linking the TGF-β (+869 C/T) Polymorphism to a Structurally Validated Natural Inhibitor

Puntos clave

Resumen

Citation Network

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

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Discussion

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